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Wellcome Believe in, Britain's greatest health-related research foundation said it experienced "significant issues" about U.S. drug significant Pfizer's (PFE.N) sixty three billion pound provide for AstraZeneca (AZN.L), the Monetary Moments documented. In a personal letter to United kingdom chancellor of Exchequer George Osborne, the have confidence in lifted uncertainties about Pfizer's commitment to investment in Britain and mentioned AstraZeneca was essential to Britain's science foundation. "Pfizer's previous acquisitions of major pharmaceutical companies have led to a substantial reduction in R&D activity, which we are worried could be replicated in this instance," Wellcome Have confidence in Chairman Sir William Castell was quoted as expressing by the British newspaper. Wellcome Have faith in grew to become the most recent in a collection of vocal opponents to the possible merger, which would generate the world's greatest drugmaker. Pfizer is explained to be taking into consideration increasing its provide following AstraZeneca turned down its preceding provide of $106 billion. The price of that funds-and-stock provide has considering that slipped simply because of a drop in Pfizer shares following weak quarterly benefits. The offer faces political scrutiny as pressure builds on Primary Minister David Cameron to defend Britain's positions and research base must it go by way of. Wellcome Trust spends more than 750 million pounds a year on biomedical investigation, in accordance to the FT. ($one = .5899 British Kilos)